Avanoxx works on a 39 seconds loop. It opens with a Voracious Bite followed by an Alerting Shrill (+00:08) and a second Voracious Bite (+00:15). At this point, you will get a brief respite to manage the adds before the Gossamer Onslaught to close the loop (+00:30).

Your tank will need help, but Alerting Shrill and its physical damage does not give you much freedom to do so, try to spare them some resources still. You will have at maximum 2 GCDs during the Shrill itself, so Absorb Effects and other "prep" effects are strong to handle this mechanic. You have some time after to top up people, focus on keeping them alive.

Gossamer Onslaught should be less threatening, but you do not have as much time to recover before the next cycle starts, do not get comfortable.

This is a very hard fight, and you will run out of cooldowns, so you will want to focus on your fundamentals to always keep a layer of safety. Focus on healing until you get more comfortable with the timings.

Looking at the damage pattern, Ki'takal is very straightforward. They simply cast Cultivated Poisons every 22 seconds. Any cadence faster than every 30 seconds raises the concern of running out of cooldowns, but that's not the main problem here. The sheer amount of movement created by the mechanics of this encounter make it an incredible challenge.

Do not play hero and focus on three things:

• Have a plan to get a Grasping Blood puddle for Cosmic Singularity every 2 Cultivated Poisons.
• Prioritize your cooldowns on the even Cultivated Poisons if you are running out of resources, as Cosmic Singularity comes right after.
• Dodge everything, Stay alive.

As a side note, To escape the Grasping Blood, you can use an anti-snare, but also simply use a control on the blood, stun, knockback, most things work. Just do not do it too early!